Under Contstruction

2016 Selected Research on Colon Cancer

Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia …

D Niedzwiecki, WL Frankel, AP Venook, X Ye… – Journal of Clinical Oncology, 2016
Purpose Conventional staging methods are inadequate to identify patients with stage II
colon cancer (CC) who are at high risk of recurrence after surgery with curative intent. ColDx
is a gene expression, microarray-based assay shown to be independently prognostic for

[HTML] Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancerpatients

F Klupp, L Neumann, C Kahlert, J Diers, N Halama… – BMC Cancer, 2016
Background Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent
endopeptidases which are involved in angiogenesis, tumor invasion and metastatic
formation. Up to date, the prognostic relevance of MMPs in serum of patients with colon

5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancercells lacking p53.

V Pagliara, A Saide, E Mitidieri, VBR d’Emmanuele… – Oncotarget, 2016
Recent findings revealed in cancer cells novel stress response pathways, which in response
to many chemotherapeutic drugs causing nucleolar stress, will function independently from
tumor protein p53 (p53) and still lead to cell cycle arrest and/or apoptosis. Since it is

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

X Li, J Guo, AP Ding, WW Qi, PH Zhang, J Lv, WS Qiu… – Technology in Cancer …, 2016
Background: The mixed lineage kinase domain-like protein has recently been identified as a
key downstream component of tumor necrosis factor–induced necroptosis, which is an
important pathway of cancer cell death. The goal of the current study is to explore the

… edible spears of wild asparagus inhibit AKT, p70S6K, and ERK signalling, and induce apoptosis through G0/G1 cell cycle arrest in human colon cancer HCT-116 cells

S Jaramillo, FJG Muriana, R Guillen, A Jimenez-Araujo… – Journal of Functional Foods, 2016
Abstract The effects of steroidal saponins from edible spears of wild triguero Huetor-Tajar
asparagus on some of the oncogenic molecular pathways that are affected in human colon
cancer cells were investigated. Reverse-phase chromatography and a new HPLC-MS

Variation in Primary Site Resection Practices for Advanced Colon Cancer: A Study Using the National Cancer Data Base

MA Healy, JC Pradarelli, R Krell, SE Regenbogen… – The American Journal of …, 2016
Methods We evaluated all patients with Stage IV cancers in the National Cancer Data Base
between 2002 and 2012 (50,791 patients, 1,230 hospitals). We first identified patient
characteristics associated with primary tumor resection. Then, we assessed nationwide

Mitochondria-targeting ratiometric fluorescent probe for g-glutamyltranspeptidase and its application to colon cancer

S Park, DJ Bae, YM Ryu, SY Kim, SJ Myung, HJ Kim – Chemical Communications, 2016
A mitochondria-targeting ratiometric probe was designed for g-glutamyltranspeptidase
(gGT). Mechanistic study through HPLC and an inhibitor assay showed that the probe
underwent gGT-mediated amide-to-amine transformation and induced a ratiometric

Synthesis of 4-thio-5-(2 ″-thienyl) uridine and cytotoxicity activity against colon cancer cells in vitro

X Zhang, D Li, J Qin, YZ Xu, K Ma – RSC Advances, 2016
A novel anti-tumor agent 4-thio-5-(2 ″-thienyl) uridine (6) was synthesized and the in vitro
cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells
(HT-29) were evaluated by MTT assay. The results showed that the novel compound had

Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium‐ATPase 3 gene (ATP2A3) in gastric and colon cancer cells

L Flores‐Peredo, G Rodríguez, A Zarain‐Herzberg – Molecular Carcinogenesis, 2016
Abstract The Sarco/Endoplasmic Reticulum Ca 2+-ATPases (SERCAs), pump Ca 2+ into the
endoplasmic reticulum lumen modulating cytosolic Ca 2+ concentrations to regulate various
cellular processes including cell growth. Previous studies have reported a downregulation

Laparoscopic surgery for left-sided colon cancer: Clinical and long-term oncologic outcomes

MK Cho, TH Kim, CN Kim, JH Jang, J Jung, MS Lee… – Korean Journal of Clinical …, 2016
Purpose: Laparoscopic surgery for left-sided colon cancer is one of the most frequent
procedures performed in laparoscopic colorectal surgery. In this study, we analyzed clinical
and long-term oncological outcomes of left-sided colon cancer patients who underwent