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2016 Selected Research on Liver Cancer

Stemness of liver cancer: from hepatitis B virus to Wnt activation

T Yamashita, JC Nault – Journal of Hepatology, 2016
Hepatocellular carcinoma (HCC) is a heterogeneous disease in terms of etiology,
morphology, biological behavior, response to treatment, and clinical outcome. Efforts have
been made on classifying HCCs according to the status of gene mutations, chromosomal

[PDF] Tumor Segmentation and Automated Training for Liver Cancer Isolation

S Mandhan, K Jain – 2016
Abstract: Image segmentation is the process of subdividing the image to into its parts that are
constituent and is considered one of the most difficult tasks in image processing. It plays a
task that is a must any application and its particular success is based on the effective

Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice

G Balandaram, LR Kramer, BH Kang, IA Murray… – Toxicology, 2016
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits steatosis and
inflammation, known risk factors for liver cancer. In this study, the effect. Highlights. •
The role of PPARβ/δ in HBV-induced liver cancer was examined. •

The hidden threat of hepatitis B

C Prevention – N Engl J Med, 2016
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Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses

C Ling, B Li, W Ma, A Srivastava – Human Gene Therapy, Part B: Methods, 2016
In our previously published studies, we identified the S663V+T492V double-mutant (DM) AAV3
vector as the most efficient vector in transducing human liver cancer cell lines 25. following
subcutaneous injection of human liver cancer lines26. NSG mice bearing human liver

Small-molecule inhibitor sorafenib regulates immunoreactions by inducing survival and differentiation of bone marrow cells

X Zhao, M Cao, Z Lu, T Wang, Y Ren, C Liu, D Nelson – Innate Immunity, 2016
Abstract. Sorafenib has been used for the treatment of liver cancer. However, its clinical impact
on human immunity system remains poorly known. Our previous study has shown that sorafenib
modulates immunosuppressive cell populations in murine liver cancer models.

Liver and biliary damages following transarterial chemoembolization of hepatocellular carcinoma: comparison between drug-eluting beads and lipiodol emulsion

A Monier, B Guiu, R Duran, S Aho, P Bize, P Deltenre… – European Radiology, 2016
Transarterial chemoembolization (TACE) is the standard of care for the treatment of hepatocellular
carcinoma (HCC) in the intermediate-stage of the Barcelona Clinic Liver Cancer staging system
(BCLC) [1]. It combines the dual benefit of the locoregional delivery of high doses

[PDF] Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells

HCH Li, YX Zhang, Y Liu, QS Wang – Genetics and molecular research: GMR, 2016
Hepatoma, or liver cancer, is a common disease that can be divided into to two major categories:
primary and secondary (Wang et al., 2010; Siegel et al., 2012). In China, liver cancer accounts
for the first and second causes of mortality in the countryside and cities, respectively.

[HTML] Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa ( …

M Lemoine, Y Shimakawa, R Njie, M Taal, G Ndow… – The Lancet Global Health, 2016
Despite the introduction of immunisation for hepatitis B virus (HBV) in the 1990s, HBV-related
morbidity and mortality remain high in sub-Saharan Africa. Identi.

Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana

T Karunakaran, GCL Ee, KH Tee, IS Ismail… – Phytochemistry Letters, 2016
and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts
were tested against two cancer cell lines, Hep G2 (liver cancer cell line) and
HT-29 (colon cancer cell line) using MTT assays. Mesuarianone (3

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.

MM Simile, G Latte, MI Demartis, S Brozzetti, DF Calvisi… – Oncotarget, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC).
Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC
chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis, than in


… /dialdehyde starch/chitosan composite coating for in-tube solid-phase microextraction and in-situ derivation to analysis of two liver cancer biomarkers in human blood

S Wu, C Cai, J Cheng, M Cheng, H Zhou, J Deng – Analytica Chimica Acta, 2016
Abstract In order to highly enrich two liver cancer biomarkers (hexanal and 2-butanone) in
human blood, in this study, natural nontoxic polydopamine/dialdehyde starch/chitosan
(PD/DAS/CHI) coating material was synthesized and immobilized on the inner wall of


[PDF] miRNA-101 affecting proliferation and invasion of liver cancer by down-regulating COX-2 expression

HW Xu, Y Li, Y Wang, J Li, ZX Li, BQ Gao, JG Wang – Int J Clin Exp Pathol, 2016
Abstract: Objective: to find out changes in the expression of miRNA-101 (miR-101) in the
liver cancer tissues and cells and the effects on proliferation and invasion of the human liver
cancer cells HepG2. Method: The expression of miR-101 and COX-2 in liver cancer and


Antitumor activity of polysaccharide from Laminaria japonica on mice bearing H22 liver cancer

Q Zhu, J Chen, Q Li, T Wang, H Li – International Journal of Biological …, 2016
Abstract Water-soluble polysaccharide was extracted from Laminaria japonica, and its
antitumor effect on mice bearing H22 liver cancer was investigated. The mice were
inoculated with H22 hepatoma cells and randomly divided into four groups: three


Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth.

A Lasfar, A de la Torre, W Abushahba, KA Cohen-Solal… – Oncotarget, 2016
NJ, USA. (7)Department of Pathology, New Jersey Medical School, Rutgers, The State
University of New Jersey, Newark, NJ, USA. Hepatocellular carcinoma (HCC) is the
most prevalent type of liver cancer. No significant improvement


Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

DJ Hughes, T Duarte-Salles, S Hybsier, A Trichopoulou… – The American Journal of …, 2016
develop- ment. Am J Clin Nutr doi: 10.3945/ajcn.116.131672. Keywords:
hepatocellular carcinoma, selenium, selenoprotein P, prospective cohort, liver cancer,
hepatobiliary cancer, selenium status INTRODUCTION Worldwide


[HTML] Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types

S Ren, Z Zhang, C Xu, L Guo, R Lu, Y Sun, J Guo… – Cell Research, 2016
cancer. For example, AUCs were 0.942 vs 0.750 and sensitivities were 84.0% vs
61.2% at the same specificity for the Gal-ratio vs AFP in detection of liver cancer
(Supplementary information, Figure S1E and Table S1E). The


FIB-4 Index is a Predictor of Background Liver Fibrosis and Long-Term Outcomes After Curative Resection of Hepatocellular Carcinoma

Y Okamura, R Ashida, Y Yamamoto, T Ito, T Sugiura… – Annals of Surgical Oncology, 2016
Page 8. CONFLICT OF INTEREST There are no conflicts of interest. REFERENCES 1. The
Liver Cancer Study Group of Japan. Primary liver cancer in Japan: clinicopathologic features
and results of surgical treat- ment. Ann Surg. 1990;211:277–87.


Adoption of new agents and changes in treatment patterns for hepatitis C: 2010-2014.

X Yao, LR Sangaralingham, JS Ross, ND Shah… – The American journal of …, 2016
The introduction of new medications was significantly associated with an increased treatment
rate, from 5.4% to 6.8% (P < .001). The increase was high among elderly patients and patients
with liver transplant, liver cancer, and liver disease or cirrhosis.


[PDF] Sirtuin-4 (SIRT4) is downregulated in hepatocellular carcinoma and associated with clinical stage

G Huang, X Lai, Z Chen, Z Yu, D Zhou, P Wang… – Int J Clin Exp Pathol, 2016
Introduction Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related
death world- wide [1]. Its incidence has increased in recent years, and there are
approximately 750,000 new cases of liver cancer diagnosed each year.