Robot Surgeries, Immunotherapies, Gene Therapies…with our increased capacities with technology, the world of cancer research and cures is exploding with possibilities. The next 10 years holds great promise. But for those of us struggling in the moment, at the end of our ropes, the future cannot come soon enough. The problem is that Cancer is not one specific disease, but rather many intersecting and interlocking diseases.
Nonetheless Precision medicine, which targets exact mutations, along with immunotherapy holds great promise as does stem cell research. Below are some of the most recent research findings. Some are more readable than others, but for you science wonks, or for those of you like me who are willful to understand, here are some peer reviewed findings from the research on cancer cures. They are categorized by subheadings: Gene Therapy, Immunotherapy, Stem Cell Research, Germ-line Therapy, etc..
2016 SELECTED TARGETED THERAPY RESEARCH FINDINGS
Improving Outcomes in Resectable Gastric Cancer: A Review of Current and Future Strategies.
E. Gastric cancer is a highly fatal malignancy, and surgery alone often does not
provide a cure, even for relatively early stages of disease. …
2016 SELECTED GENE THERAPY RESEARCH FINDINGS
Twelfth Annual Meeting of the French Society of Cell and Gene Therapy
Marc Kay’s group has developed an AAV promoterless gene-targeting approach without the use
of nucle- ases and used this tactic to successfully treat mice with …
Cancer suicide gene therapy: a patent review
despite the progress made in early detection and advances in classical therapies.
Advancing in the fight against cancer requires the development of novel strategies, and …
The Target’s the Thing
1970s, many conceived of the Nixon administration’s “War on Cancer” as the search for a single
breakthrough that would allow for effective treatment of all forms of cancer, as if cancer …
Theranostic Imaging of Cancer Gene Therapy
approach for treating cancers of various phenotypes. This strategy is independent of various
other chemotherapeutic drugs used for treating cancers where the drugs are mainly …
… Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 …
of the stage II cohort in Intergroup 0035 suggested that fluorouracil therapy might be … a direction
for future research would be to show that prognostic gene expression signatures …
[HTML] The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer
essential for uncovering the underlying mechanisms of EC for therapy improvement … cell
proliferation, differentiation, transcriptional, and post-transcriptional regulators of gene activity [ …
The present and future of genome editing in cancer research
genome … a mutation in the FAH gene in the liver has been used to treat a mouse … associated virus
(AAV), was recently shown to significantly improve the efficiency of FAH gene repair in …
Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses
following subcutaneous injection of human liver cancer lines26. NSG mice bearing human liver …
Human gene therapy for RPE65 isomerase … Treatment of leber congenital …
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE
with a non-dsRNA therapeutic agent, such as an agent known to treat a cancer … be administered
with, eg, a chemotherapeutic agent, such as temozolomide, or with radiation therapy. …
Nanoparticle-Mediated Delivery of Suicide Genes in Cancer Therapy
to their efficacy in killing the malignant cells, but the other side of th.
2016 SELECTED IMMUNOTHERAPY RESEARCH FINDINGS
Immunobiology and immunotherapy in genitourinary malignancies
armamentarium in genitourinary (GU) cancers. It has an established role in the management
of carefully selected patients with metastatic renal cell carcinoma (RCC)[eg, high dose …
[PDF] Mutated neo-antigens as targets for individualized cancer immunotherapy
evidence suggests that a significant subset of mutations result in neo-epitopes recognized
by tumor-specific T cells and thus may constitute the Achilles’ heel of malignant cells. T …
Vaccination Against Breast Cancer and its Role in Prevention
overexpressing breast cancer: current status and future perspectives. Ann Oncol. … Page DB, Naidoo
J, McArthur HL. Emerging immunotherapy strategies in breast cancer. Immunotherapy. …
M2 polarization of murine peritoneal macrophages induces regulatory cytokine production and suppresses T‐cell proliferation
studies have been performed with … cancer (19–22). Immunotherapy studies advance not
only the field of cancer but also the field of inflammatory disease. …
Efficient regeneration of Human Vα24+ invariant NKT cells and their anti‐tumor activity in vivo
ABSTRACT … This study thus provides a first proof of concept for the clinical application of human
iPS-Vα24+iNKT cells for cancer immunotherapy. STEM CELLS 2016; 00:000–000 …
Clinical and prognostic significance of PD-1 and PD-L1 expression in sarcomas
death-ligand 1 (PD-L1) are new targets in cancer immunotherapy in recent years. … Keywords.
PD-1 PD-L1 Immunotherapy Sarcoma. This study has been submitted to ESMO 2016 meeting. ..
Innovation in Bladder Cancer Immunotherapy.
response to immunotherapy. Indeed, funding for studies to explore mechanisms of tumor
immunity and novel new therapeutics is disproportionately lower for bladder cancer in …
Immunotherapy in non-small cell lung cancer: the clinical impact of immune response and targeting
death worldwide. In recent years, through a better understanding of the interactions between
the immune system and tumor cells (TC), immunotherapy has emerged as a promising …
Prospecting TCRs for immunotherapy
cells is an attractive option but is technically challenging because of difficulties in raising
robust and appropriate immune responses. In Science, Schumacher and colleagues study …
[HTML] Cancer immunotherapy trials: leading a paradigm shift in drug development
orthopedic surgeon in the late 1800’s who noted marked tumor regression in a patient with
severe erysipelas. Based on this observation, he hypothesized that stimulating the …
[HTML] Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumorimmunotherapy in the absence of SHP-1
cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some
patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein …
CIMT 2016: Mechanisms of efficacy in cancer immunotherapy-Report on the 14th Annual Meeting of the Association for Cancer Immunotherapy
cancer. Its well-established preclinical era has been flourishing in the recent decade with
many patients benefiting from the therapeutic efficacy of cancer immunotherapy through …
Melanoma immunotherapy dominates the field
and intervention, the number of patients dying from metastatic disease continues to rise. The
prognosis of advanced melanoma remains poor, with median survival between 6 and 9 …
Human γδ T cells: From a neglected lymphocyte population to cellular immunotherapy: A personal reflection of 30years of γδ T cell research
1, 2016. Please refer to this blog post for more information. Close. ScienceDirect.
Sign in Sign in using your ScienceDirect credentials. Username. …
Cellular immunotherapy for malignant gliomas
Clinical trials evaluating a variety of immunotherapeutic approaches are underway in
patients with malignant gliomas. Thanks to recent advancements in cell engineering …
[HTML] A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy
emerging approach for the induction of tumor-specific immune responses. Memory stem T
cells, due to their enhanced antitumor and self-renewal capacity, have become potential …
[HTML] Expression of CCL21 in Ewing sarcoma shows an inverse correlation with metastases and is a candidate target for immunotherapy
and has a poor prognosis when metastasized. For patients with metastatic disease in
particular, immunotherapy has been proposed as possible beneficial additive therapy. …
Comparing Small Molecule, Immunotherapy and Combination Therapies for Colon Cancer
cells to understand the efficacy of small molecule and immunotherapy drugs used
individually in comparison to combination therapy solutions. We hope that using the small …
Updates on Therapies for Metastatic RCC
to be an “immunogenic” tumor due to its ability to evade tumor immune surveillance.
For the past … Future Immunotherapy Strategies. Based on the …
[PDF] Cell reactions and immune responses to photodynamic therapy in oncology
offer not only simple destruction of the primary tumor but also stimulation of the host immune
system to recognize, track down, and ultimately destroy tumor cells that have metastasized …
2016 SELECTED STEM CELL RESEARCH FINDINGS
Cancer stem cell and treatment of breast cancer
to cure cancer patients. American Journal of Cancer Research 2012; 2: 340-356. Jones RJ, Matsui
WH, and Smith BD. Cancer Stem Cells: Are We Missing the Target? ..
Bruceantin inhibits multiple myeloma cancer stem cell proliferation
cancer stem cells (CSCs) have been demonstrated to sustain tumor growth. Due to their
ability to self-renew and to express detoxifying enzymes and efflux transporters, MM-CSCs …
PNR-17HIGH-DOSE CHEMOTHERAPY WITH STEM CELL TRANSPLANT TO DELAY RADIATION IN PEDIATRIC EMBRYONAL BRAIN TUMOR PATIENTS
Outcomes with adjuvant high-dose chemotherapy and stem cell transplant are comparable to
adjuvant craniospinal chemoradiation in select pediatric embryonal brain tumor patients. …
… RESECTED C19MC NEGATIVE EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES (ETMR) USING HIGH DOSE CHEMOTHERAPY AND STEM CELL …
EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES (ETMR) USING HIGH DOSE
CHEMOTHERAPY AND STEM CELL TRANSPLANT: CASE REPORT AND LITERATURE REVIEW …
Comparable outcomes following two or three cycles of high-dose chemotherapy and autologousstem cell transplantation for patients with relapsed/refractory germ …
PubMed | ISI | CAS |; International Germ Cell Cancer Collaborative Group. … cell consensus
classification: a prognostic factor-based staging system for metastatic germ cell cancers. …
[HTML] … Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell …
with guidelines from the Mouse Models of Human Cancers Consortium (MMHCC … therapy-related
AML samples were CD3-depleted using Robosep (Stem Cell Technologies, Vancouver …
Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer
combination with high-dose combination chemotherapy and stem cell transplant in … need to fulfill
several requirements, including availability of a multidisciplinary tumor board and a …
[HTML] MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma
in human cancers [4, 5 … It has been suggested that repression of these stemness-inhibiting miRNAs
maintains the stem cell phenotype and is implicated in cancer progression [13 …
Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.
analyzed the plasticity of lung cancer cells and found that lung non-CSCs/CICs can dedifferentiate
into CSCs/CICs in accordance with the expression of stem cell transcription factor …
uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy.
system in head and neck squamous cell carcinoma (HNSCC), particularly … linked to the induction
of epithelial-to-mesenchymal transition, the acquisition of stem cell properties and …
… aortic arch banding and debanding in mice as a model of pressure overload hypertrophy182Late sodium current inhibitors for the treatment of inducible obstruction …
metabolism of cardiac progenitor cells: a first step towards controlling their proliferation and
differentiation? 73Expression of pw1/peg3 identifies a new cardiac adul…| Cardiovascular …
The effect of salvage autologous stem–cell transplantation on overall survival in patients with relapsed multiple myeloma (final results from BSBMT/UKMF Myeloma X …
underwent peripheral blood stem–cell remobilisation 18 and 174 patients were … demographic and
disease characteristics were well balanced between the treatment groups (table 1 …
[HTML] Tumor prevention facilitates delayed transplant of stem cell‐derived motoneurons
to prevent cancer formation.[16, 42] Tumor formation has been seen following the transplantation
of a number of cell types, including various human pluripotent cell lines.[43-47 …
Mechanisms of Cancer-related Cardiomyopathy67Protection against chemotherapy cardiotoxicity by the human amniotic fluid stem cell secretome: a new tool for …
a … Introduction: Advances in diagnosis and therapy have made cancer curable in a substantial …
such as anthracyclines, may become the major health problem in cancer survivors. …
… of Epstein-Barr Virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: Sixth European …
Research and Treatment of Cancer (EORTC-IDG), the … To better define current understanding
of post-transplant lymphoproliferative disorders in stem cell transplant patients, and to …
[HTML] Wnt Signaling in Cancer Stem Cell Biology
targeting of the Wnt pathway is unlikely to show efficacy in cancers with genetic … of a subset of
Wnt target genes that are particularly important for (cancer) stem cell proliferation [106 …
Contribution of INTRAMUSCULAR Autologous Adipose Tissue-Derived Stem Cell Injections toTreat Cutaneous Radiation Syndrome: Preliminary Results
dose located irradiation is characterized by d.
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
transcription and … MB-468; M157, MDA-MB-157; M231, MDA-MB-231; RCC, renal cell carcinoma. …
To study this further, we made an Hs578T breast cancer subclone harboring a firefly …
[PDF] YAP down-regulated its target CTGF to maintain stem cell pluripotency in human ovariancancer stem-like cells
F, Bernasconi S, Perego P, Ganzinelli M, Russo G, Bono F, Mangioni C, Fruscio R, Signorelli M,
Broggini M, Damia G. Ovarian car- cinoma tumor-initiating cells have a …
[PDF] Synergistic Chemo–Photothermal Therapy of Breast Cancer by Mesenchymal Stem Cells Encapsulated Yolk–Shell GNR@ HPMO-PTX Nanospheres
therapy.8 It is found that the therapeutic agents delivered by MSCs are homogeneously and
enduringly distributed in the tumor, which is favorable for improving treatment efficacy.6,9 However …
2016 SELECTED INDUCTION RESEARCH FINDINGS
The Role of Induction Therapy for Esophageal Cancer
radiation therapy before esophagectomy for esophageal cancer. Role of induction therapy.
Surgery is considered integral to achieving cure in patients with esophageal cancer. …
2016 SELECTED GERMLINE RESEARCH FINDINGS
Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer
clinical scenarios in advanced germ cell cancer (GCC). Objective. To … caution. HDCT
can cure a significant proportion of heavily treated GCC patients. …
[HTML] Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL
germline variants, 20 localized in genes and 3 in intergenic regions. … In a candidate gene approach,
the genes were selected based on their involvement in metabolic pathways …
PATIENT-SPECIFIC STEM CELL LINES DERIVED FROM HUMAN PARTHENOGENETIC BLASTOCYSTS
of the present invention can also be differentiated into derivatives of all three germ layers in …
pluripotent cells and cell lines, preferably human pluripotent cells and cell lines, which are …
The present and future of genome editing in cancer research
it is important to consider that CRISPR-based somatic genome editing and conventional germ
line gene– targeting methods are … The library is then transduced into the desired cell line. …
Serous ovarian and primary peritoneal cancers: A comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome
also in women carrying a germline BRCA mutation after prophylactic oophorectomy [3]. In some
cases primary … BRCA germ–line mutation, 0.500. … Lines of systemic therapy, 0.247. …
The role of precision medicine for the treatment of metastatic renal cell carcinoma.
versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival …
onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine …
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes
inhibition in one of the three wild-type PIK3CA ovarian cancer cell lines, e.g … lethality by inhibiting
PARP in tumor cells harboring BRCA deficiency caused by germline mutation, somatic …
[PDF] Analysis of PBase Binding Profile Indicates an Insertion Target Selection Mechanism Dependent on TTAA, But Not Transcriptional Activity
AE, Crisanti A, Catteruccia F. piggyBac-mediated germline transformation of the … piggyBac
transposition into primordial germ cells is an efficient tool for transgenesis in chickens. …
In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity
cell lines. … all, 22 compounds were analyzed for their toxicity levels on Leydig and germ cells
(Fig. … 34 °C, 5% CO 2 . Despite its unknown metabolic competency, this cell line has been …
Personalized treatment of prostate cancer: better knowledge of the patient, the disease and the medicine
with defects in other cancer-related genes and 8% with actionable pathogenic germline alterations
[3 … in 49 patients with mCRPC who had received one to two prior lines of taxane. …
Smart micelleplexes as a new therapeutic approach for RNA delivery
guaranteeing the silencing, correction or introduction of specific genes with minimal … application
in gene therapy owing to their unique beneficial features: a peculiar core- …