Under Construction

2016 Selected Pancreatic Cancer Research

Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C

T Hanaki, Y Horikoshi, K Nakaso, M Nakasone… – Biochimica et Biophysica …, 2016
Background Pancreatic cancer (PC) is the most lethal malignancy among solid tumors, and
the most common risk factor for its development is cigarette smoking. Atypical protein kinase
C (aPKC) isozymes function in cell polarity, proliferation, and survival, and have also been

[PDF] … sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary …

J Yu, Y Sadakari, K Shindo, M Suenaga, A Brant… – Gut, 2016
Objective Secretin-stimulated pancreatic juice contains DNA shed from cells lining the
pancreatic ducts. Genetic analysis of this fluid may form a test to detect pancreatic ductal
neoplasia. Design We employed digital next-generation sequencing (‘digital NGS’) to

siRNA-coupled nanoparticles for improved therapeutic targeting of pancreatic cancer

S Lange, D Saur, R Rad – Gut, 2016
Pancreatic cancer (PC) is one of the most lethal malignancies, characterised by a poor
response to conventional chemotherapy and rapid development of secondary resistances.
Compared with most other digestive tract cancers, progress in PC treatment has been

pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

DRP Sauter, CE Sørensen, M Rapedius… – Biochimica et Biophysica …, 2016
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and
new therapeutic targets are urgently needed. One of the hallmarks of cancer is changed pH-
homeostasis and potentially pH-sensors may play an important role in cancer cell

D‐dopachrome tautomerase is over‐expressed in pancreatic ductal adenocarcinoma and acts cooperatively with macrophage migration inhibitory factor to promote …

D Guo, J Guo, J Yao, K Jiang, J Hu, B Wang, H Liu… – International Journal of …, 2016
Shenyang, China Running title: DDT and MIF act cooperatively to promote pancreatic
cancer growth Keywords: D-dopachrome tautomerase, macrophage migration inhibitory
factor, pancreatic cancer, proliferation, tumor growth, invasion

[HTML] Opium use, cigarette smoking, and alcohol consumption in relation to pancreatic cancer

R Shakeri, F Kamangar, M Mohamadnejad, R Tabrizi… – Medicine, 2016
Abstract Background and Aims: Although several studies have suggested opium as a risk
factor for cancers of the esophagus, stomach, larynx, lung, and bladder, no previous study
has examined the association of opium with pancreatic cancer. We aimed to study the

LncRNAs in pancreatic cancer.

X Huang, X Zhi, Y Gao, N Ta, H Jiang, J Zheng – Oncotarget, 2016
Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The
underlying mechanism of PC is not completely understood at present. Studies in recent
years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological

[HTML] Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1α and TGFβ and Implications for Migration of Pancreatic Cancer Cells

V Tjomsland, E Pomianowska, M Aasrum, D Sandnes… – Neoplasia, 2016
Abstract Pancreatic ductal adenocarcinoma is characterized by a prominent
fibroinflammatory stroma with both tumor-promoting and tumor-suppressive functions. The
pancreatic stellate cell (PSC) is the major cellular stromal component and the main

Borderline resectable pancreatic cancer: Need for standardization and quality control in clinical treatment trials

MHG Katz – Pancreatology, 2016
Chemotherapy and/or chemoradiation is often recommended to patients with borderline
resectable pancreatic cancer prior to planned pancreatectomy, but methodological
limitations of prior clinical studies have prevented a complete understanding of the role of

Impact by pancreatic stellate cells on epithelial-mesenchymal transition and pancreatic cancer cell invasion: adding a third dimension in vitro

E Karnevi, AH Rosendahl, KS Hilmersson, MA Saleem… – Experimental Cell Research, 2016
Abstract Pancreatic cancer is associated with a highly abundant stroma and low-grade
inflammation. In the local tumour microenvironment, elevated glucose levels, the presence
of tumour-associated stellate cells and macrophages are hypothesized to promote the